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PPAR-γ (E157) polyclonal antibody（KU）

货号: AP0688

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0688

Product Name :PPAR-γ (E157) polyclonal antibody（KU）

Swiss-Prot :P37231

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PPAR-γ (E157) polyclonal antibody detects endogenous levels of PPAR gamma protein.

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,MTOR signaling,

Alternative Name :Peroxisome proliferator-activated receptor gamma; Short name=PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG; NR1C3; PPAR γ; PPARγ

Immunogen :Synthetic peptide, corresponding to amino acids 150-200 of Human PPAR-γ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PPAR-γ (E157) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:A2780 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:AML-12 whole cell lysate(40ug)

Ibuprofen attenuates nephropathy in streptozotocin‑induced diabetic rats

JournalMolecular Medicine Reports

ApplicationWB

IF1.851

SpeciesRat

PMID27109015