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SIGLEC8 monoclonal antibody

货号: MB23124

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB23124

Product Name :SIGLEC8 monoclonal antibody

Swiss-Prot :Q9NYZ4

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983])</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :54kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SAF2; SIGLEC-8; SIGLEC8L

Immunogen :Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using SIGLEC8 mouse mAb against mouse Liver (1), rat Liver (2)tissues lysate, MCF-7 (3), and HT-29 (4) cell lysate.

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissues using SIGLEC8 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）