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BAX monoclonal antibody

货号: MB23045

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23045

Product Name :BAX monoclonal antibody

Swiss-Prot :Q07812

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200-1/1000 FC:1/200-1/400

Background :The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :21.2kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BCL2L4

Immunogen :Purified recombinant fragment of human BAX(AA: (13-160)) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using BAX mouse mAb against Hela (1), C2C12 (2),C6 (3),HepG2 (4),MCF-7 (5),Ramos (6),Raji (7),HEK293 (8), and HEK293-6e (9) cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using BAX mouse mAb with DAB staining.