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ERCC1 monoclonal antibody

货号: MB23020

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB23020

Product Name :ERCC1 monoclonal antibody

Swiss-Prot :P07992

Host :Mouse

Reactivity :Human, Mouse

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200-1/1000 FC:1/200-1/400

Background :The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :32.5kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :UV20; COFS4; RAD10

Immunogen :Purified recombinant fragment of human ERCC1 (AA: 1-297) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using ERCC1 mouse mAb against NIH/3T3 (1), MCF-7 (2), Hela (3), SK-Br-3 (4), HepG2 (5), Raji (6), PC-3 (7), and K562 (8) cell lysate.

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using ERCC1 mouse mAb with DAB staining.