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MLH1 monoclonal antibody

货号: MB22919

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB22919

Product Name :MLH1 monoclonal antibody

Swiss-Prot :P40692

Host :Mouse

Reactivity :Human

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200-1/1000 FC:1/200-1/400

Background :The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :84.6kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FCC2; COCA2; HNPCC; hMLH1; HNPCC2

Immunogen :Purified recombinant fragment of human MLH1 (AA:381-483) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using MLH1 mouse mAb against Hela (1), Jurkat (2), A431 (3), HepG2 (4), and MCF-7 (5) cell lysate.

Immunohistochemical analysis of paraffin-embedded human Colon cancer tissues using MLH1 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）