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SETD7 monoclonal antibody

货号: MB22750

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB22750

Product Name :SETD7 monoclonal antibody

Swiss-Prot :Q8WTS6

Host :Mouse

Reactivity :Human,Rat,Monkey

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.</p>

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :40.7kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KMT7; SET7; SET9; SET7/9

Immunogen :Purified recombinant fragment of human SETD7 (AA: 107-366) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using SETD7 mouse mAb against MCF-7 (1), Hela (2), A549 (3), COS7 (4), Jurkat (5), and PC-12 (6) cell lysate.

Immunohistochemical analysis of paraffin-embedded human Hela tissues using SETD7 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）