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KIR3DL1 monoclonal antibody

货号: MB22479

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22479

Product Name :KIR3DL1 monoclonal antibody

Swiss-Prot :P43629

Host :Mouse

Reactivity :Human,Rat

Applications :WB,FCM

Application_all :WB:1/500 - 1/2000 FC:1/200 - 1/400

Background :Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.<br />

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :49kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1

Immunogen :Purified recombinant fragment of human KIR3DL1 (AA: extra 22-340) expressed in HEK293 cells.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using KIR3DL1 mouse mAb against A431 (1), Raji (2), SPC-A-1 (3), K562 (4), HEK293 (5), U937 (6), and C6 (7) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）