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ADORA2A monoclonal antibody

货号: MB22417

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22417

Product Name :ADORA2A monoclonal antibody

Swiss-Prot :P29274

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey

Applications :WB,IF,FCM

Application_all :WB:1/500-1/1000 IF:1/100 - 1/500 FC:1/200 - 1/400

Background :This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.<br />

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2a

BiowMW :44.7kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :A2aR; RDC8; ADORA2

Immunogen :Purified recombinant fragment of human ADORA2A (AA: 274-412) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using ADORA2A mouse mAb against CHO3D10(1),COS7(2),F9(3),L1210(4),C6(5),C2C12(6),NIH/3T3(7),Raw264.7(8) cell lysate.

Immunofluorescence analysis of Hela cells using ADORA2A mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)