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CHRNA7 monoclonal antibody

货号: MB22382

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB22382

Product Name :CHRNA7 monoclonal antibody

Swiss-Prot :P36544

Host :Mouse

Reactivity :Human,Rat

Applications :WB,FCM

Application_all :WB:1/500 - 1/2000 FC:1/200 - 1/400

Background :The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.<br />

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :56.4kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NACHRA7; CHRNA7-2

Immunogen :Purified recombinant fragment of human CHRNA7 (AA: extra 52-259) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CHRNA7 mouse mAb against membrane protein lysate of C6 (1), membrane protein lysate of SK-N-SH (2), C6 (3), and HepG2 (4) cell lysate.