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WAS monoclonal antibody

货号: MB21886

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21886

Product Name :WAS monoclonal antibody

Swiss-Prot :P42768

Host :Mouse

Reactivity :Human

Applications :IHC,FCM

Application_all :IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2a

BiowMW :53kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :THC; IMD2; SCNX; THC1; WASP

Immunogen :Purified recombinant fragment of human WAS (AA: 57-170) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using WAS mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）