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CDH16 monoclonal antibody

货号: MB21841

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21841

Product Name :CDH16 monoclonal antibody

Swiss-Prot :O75309

Host :Mouse

Reactivity :Human

Applications :WB,IHC,IF,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :90kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KSP-Cadherin

Immunogen :Purified recombinant fragment of human CDH16 (AA: EX(558-721)) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CDH16 mouse mAb against A431 (1), Jurkat (2) cell lysate.

Immunohistochemical analysis of paraffin-embedded human kidney tissues using CDH16 mouse mAb with DAB staining.

Immunofluorescence analysis of A431 cells using CDH16 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of A431 cells using CDH16 mouse mAb (green) and negative control (red).