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NBN monoclonal antibody

货号: MB21797

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21797

Product Name :NBN monoclonal antibody

Swiss-Prot :O60934

Host :Mouse

Reactivity :Human,Rat

Applications :WB,IHC,IF,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2a

BiowMW :85kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ATV; NBS; P95; NBS1; AT-V1; AT-V2

Immunogen :Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using NBN mouse mAb against A549 (1), Jurkat (2) and PC-12 (3) cell lysate.

Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using NBN mouse mAb with DAB staining.

Immunofluorescence analysis of Hela cells using NBN mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Hela cells using NBN mouse mAb (green) and negative control (red).