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CTCF monoclonal antibody

货号: MB21417

价格：￥ 1200

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :MB21417

Product Name :CTCF monoclonal antibody

Swiss-Prot :P49711

Host :Mouse

Reactivity :Human,Monkey

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :83kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CTCF

Immunogen :Purified recombinant fragment of human CTCF expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CTCF mouse mAb against A31 (1), MCF-7 (2), Hela (3), HCT116 (4), Jurkat (5), NIH/3T3 (6), and Cos7 (7) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）