产品类别

联系我们

电话:18013895086

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

SNAI1 monoclonal antibody

货号: MB21413

价格：￥ 1200

货期：现货（1-2个工作日）

25ug 50ug 100ug 200ug

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB21413

Product Name :SNAI1 monoclonal antibody

Swiss-Prot :O95863

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB:1/500-1/1000

Background :Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :29kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1

Immunogen :Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using SNAI1 mouse mAb against NTERA-2 cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）