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CDH1 monoclonal antibody

货号: MB21396

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21396

Product Name :CDH1 monoclonal antibody

Swiss-Prot :P12830

Host :Mouse

Reactivity :Human,Mouse,Rat,Rabbit

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :135kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1；E-cadherin；E cadherin

Immunogen :Purified recombinant fragment of human CDH1 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CDH1 mouse mAb against LNCAP (1)?A431 (2), DU145 (3), PC-3 (4), PC-12 (5) and T47D(6) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）