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STAT5B monoclonal antibody

货号: MB21349

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21349

Product Name :STAT5B monoclonal antibody

Swiss-Prot :P51692

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :90kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :STAT5; STAT5B

Immunogen :Purified recombinant fragment of human STAT5B expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using STAT5B mouse mAb against Hela (1), K562 (2), NIH/3T3 (3), C6 (4), HEK293 (5), Jurkat (6) and HL-60 (7) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）