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MAP2K2 monoclonal antibody

货号: MB21301

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21301

Product Name :MAP2K2 monoclonal antibody

Swiss-Prot :P36507

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB,IF,FCM

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :44kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MEK2; MKK2; MAPKK2

Immunogen :Purified recombinant fragment of human MAP2K2 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using MAP2K2 mouse mAb against PC-12 (1), Jurkat (2), Hela (3) and NIH/3T3 (4) cell lysate.

Immunofluorescence analysis of Hela cells using anti-MAP2K2 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.