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Metadherin monoclonal antibody

货号: MB21268

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21268

Product Name :Metadherin monoclonal antibody

Swiss-Prot :Q86UE4

Host :Mouse

Reactivity :Human

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 FC:1/200 - 1/400

Background :Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :64kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :3D3; AEG1; LYRIC; MTDH

Immunogen :Purified recombinant fragment of human Metadherin expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using Metadherin mouse mAb against K562 (1), SKBR-3 (2), T47D (3), Hela (4) and MCF-7 (5) cell lysate.

Immunohistochemical analysis of paraffin-embedded human Liver tissues using Metadherin mouse mAb

免疫沉淀（IP）

免疫组织化学（IHC）