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PTEN monoclonal antibody

货号: MB21264

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21264

Product Name :PTEN monoclonal antibody

Swiss-Prot :P60484

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IF,FCM

Application_all :WB:1/500 - 1/2000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :54kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :BZS; MHAM; TEP1; PTEN1

Immunogen :Purified recombinant fragment of PTEN expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using PTEN mouse mAb against Hela (1) and NIH/3T3 (2) cell lysate.

Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using PTEN mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.