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PYK2 monoclonal antibody

货号: MB21159

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB21159

Product Name :PYK2 monoclonal antibody

Swiss-Prot :Q14289

Host :Mouse

Reactivity :Human

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2a

BiowMW :115.8kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PKB; PTK; CAKB; FAK2; FRNK; PTK2B

Immunogen :Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using PYK2 mouse mAb against Raji (1), PMA induced THP-1 (2), Jurkat (3) and Ramos (4) cell lysate.

Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using PYK2 mouse mAb.

免疫沉淀（IP）

免疫组织化学（IHC）