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DDR2 monoclonal antibody

货号: MB21128

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21128

Product Name :DDR2 monoclonal antibody

Swiss-Prot :Q16832

Host :Mouse

Reactivity :Human,Mouse,Rat,Rabbit

Applications :IHC,IF,FCM

Application_all :IHC:1/200 - 1/1000 IF:1/200 - 1/1000 FC:1/200 - 1/400

Background :DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2a

BiowMW :96.7kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TKT; MIG20a; NTRKR3; TYRO10

Immunogen :Purified recombinant fragment of human DDR2 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemical analysis of paraffin-embedded human skeletal musle tissues using DDR2 mouse mAb.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）