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LYN monoclonal antibody

货号: MB21103

价格：￥ 1200

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB21103

Product Name :LYN monoclonal antibody

Swiss-Prot :P07948

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB:1/500 - 1/2000

Background :Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG2b

BiowMW :56kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :JTK8; FLJ26625

Immunogen :Purified recombinant fragment of LYN expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using LYN mouse mAb agains HL60 (1), L540 (2), SLLP-M2 (3), SEM (4) and Ramos (5) cell lysate.

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）