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ZAP70 monoclonal antibody

货号: MB21064

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21064

Product Name :ZAP70 monoclonal antibody

Swiss-Prot :P43403

Host :Mouse

Reactivity :Human

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :ZAP70 (zeta-chain associated protein kinase), a 70 kDa member of the SYK tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. ZAP70 controls TCR(T-cell antigen receptor)-linked signal transduction pathways. Its key role in thymocytes development and mature T lymphocytes activation has been illustrated by the characterization of several human immunodeficiencies presenting with mutations in the ZAP70 gene. ZAP70 is also expressed in several types of B-cell neoplasm and is easily detected by immunohistochemistry, providing a useful prognostic marker in patients with chronic lymphocytic leukaemia.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :70kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :SRK; STD; TZK

Immunogen :Purified recombinant fragment of human ZAP70 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using ZAP70 mouse mAb against Jurkat cell lysate (1).

Immunohistochemical analysis of paraffin-embedded human lymph tumor, showing cytoplasmic localization using ZAP70 mouse mAb with DAB staining

免疫沉淀（IP）

免疫组织化学（IHC）