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Trim5a monoclonal antibody

货号: MB21040

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21040

Product Name :Trim5a monoclonal antibody

Swiss-Prot :Q9C035

Host :Mouse

Reactivity :Human

Applications :WB,IHC

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000

Background :TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RNF88; TRIM5alpha

Immunogen :Purified recombinant fragment of human trim5 alpha expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using Trim5a mouse mAb against human breast carcinoma tissue lysate.

Immunohistochemical analysis of paraffin-embedded human metastatic adenocarcinoma(A) and stomach adenocarcinoma (B), showing cytoplasmic localization using Trim5a mouse mAb with AEC staining (A) and DAB staining(B).