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BIRC2 monoclonal antibody

货号: MB0128

价格：￥

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB0128

Product Name :BIRC2 monoclonal antibody

Swiss-Prot :Q13490

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000

Background :Three mammalian homologs of baculovirus p35, designated MIHA (mammalian IAP homolog A), MIHB and MIHC have been described. These three mammalian inhibitor of apoptosis proteins (IAPs) are designated XIAP, c-IAP1 and c-IAP2, respectively. XIAP, c-IAP1 and c-IAP2 share an N-terminal baculovirus IAP repeat (BIR) motif and a C-terminal RING finger. Although c-IAP1 and c-IAP2 do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. The interaction between the TRAF1/TRAF2 heterocomplexes and c-IAPs is dependent on a functional BIR motif.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :BIRC2 mAb detects endogenous levels of BIRC2 protein.

BiowMW :Predicted band size:70KDa Observed band size:70KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Necrotic Cell Death,Death Receptor Signaling,

Alternative Name :Baculoviral IAP repeat-containing protein 2; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2; API1; IAP2; MIHB; RNF48

Immunogen :Recombinant full length Human BIRC2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of BIRC2 in K562 cell lysates and using BIRC2 antibody (1:1000 diluted) .