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ERCC1 polyclonal antibody

货号: BS8468

价格：￥

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS8468

Product Name :ERCC1 polyclonal antibody

Swiss-Prot :P07992

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF

Application_all :WB 1:500 - 1:2000 IF 1:50 - 1:200

Background :Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endonuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ERCC1 polyclonal antibody detects endogenous levels of ERCC1 protein.

BiowMW :~ 38kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA excision repair protein ERCC-1; : ERCC1

Immunogen :Recombinant full length Human ERCC1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using ERCC1 antibody.

Immunofluorescence analysis of HeLa cells using ERCC1 antibody.

Immunofluorescence analysis of U2OS cells using ERCC1 antibody.Blue: DAPI for nuclear staining.

免疫沉淀（IP）