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Cleaved-ITI-H1 (D672) polyclonal antibody

货号: BS7037

价格：￥

货期：现货（1-2个工作日）

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No. :BS7037

Product Name :Cleaved-ITI-H1 (D672) polyclonal antibody

Swiss-Prot :P19827

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The inter-α trypsin inhibitor (ITI) family is a group of structurally related plasma serine protease inhibitors synthesized in the liver and built up from different combinations of three highly homologous heavy chains (ITI-H1, ITI-H2 and ITI-H3) and one light chain (Bikunin). A fourth member of the ITI family, ITI-H4 (also known as I a IH4P) harbors a Pro-rich region (PRR) in its C-terminus. ITI is a glycoprotein composed of three polypeptides linked by chondroitin sulphate: two heavy chains, ITI-H1 and ITI-H2, and Bikunin. Bikunin confers the protease-inhibitor function of ITI. The heavy chains of the ITI family, designated as SHAPs (for serum-derived hyaluronan-associated proteins), bind covalently to hyaluronic acid (HA), resulting in pericellular matrix stabilization. ITI-H1 contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells. Although ITI-H1, ITI-H3 and Bikunin have antitumoral and antimetastatic properties in the cell, they are also associated with malignant transformation of lung tissue. ITI-H1 and ITI-H2 are associated with calcium oxalate stone formation in kidney and urine.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cleaved-ITI-H1 (D672) polyclonal antibody detects endogenous levels of Cleaved-ITI-H1 (71 kDa) protein.

BiowMW :~ 71, 101 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; Serum-derived hyaluronan-associated protein; SHAP; ITIH1; IGHEP1

Immunogen :Synthetic peptide, corresponding to amino acids 650-700 of Human ITI-H1.

Conjugate :Unconjugated

Modification :Cleaved

Western blot (WB) analysis of Cleaved-ITI-H1 (D672) polyclonal antibody pAb at 1:500 dilution Lane1:A549 cell lysate Lane2:Mouse lung tissue lysate Lane3:Rat kidney tissue lysate