Product Name :SUCNR1 polyclonal antibody
Reactivity :Human, Mouse, Rat, Pig
Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200
Background :GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :SUCNR1 polyclonal antibody detects endogenous levels of SUCNR1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :GPR91; Succinate receptor 1; G-protein coupled receptor 91; P2Y purinoceptor 1-like
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SUCNR1.
