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ATM (phospho-S1981) polyclonal antibody

货号: BS64019

价格：￥

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS64019

Product Name :ATM (phospho-S1981) polyclonal antibody

Swiss-Prot :Q13315

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-ATM (S1981) polyclonal antibody detects endogenous levels of ATM protein only when phosphorylated at ser1981.

BiowMW :~ 370 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated; ATM

Immunogen :A synthetic peptide corresponding to residues in Human ATM around the phosphorylation site of ser1981.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-ATM (S1981) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate treated with colchicine(0.2ng/ml,24h) Lane2:Raw264.7 whole cell lysate treated with colchicine(0.2ng/ml,24h) Lane3:H9C2 whole cell lysate treated with colchicine(0.2ng/ml,24h)