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Dab1 (phospho-Y232) polyclonal antibody

货号: BS4643

价格：￥

货期：现货（1-2个工作日）

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No. :BS4643

Product Name :Dab1 (phospho-Y232) polyclonal antibody

Swiss-Prot :O75553

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl. Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants. Reelin is a secreted protein thought to play a role in directing migrating neurons. Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Dab1 (Y232) polyclonal antibody detects endogenous levels of Dab1 protein when phosphorylated at Tyr232

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Disabled homolog 1; DAB1

Immunogen :Synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyrosine 232.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of Dab1 (phospho-Y232) polyclonal antibody at 1:1000 dilution Lane1:LO2 whole cell lysate(38ug) Lane2:The Brain tissue lysate of Rat(44ug) Lane3:The Brain tissue lysate of Mouse(39ug)