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Phospho-JAK2 (Tyr1007) polyclonal antibody

货号: BZ16410

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BZ16410

Product Name :Phospho-JAK2 (Tyr1007) polyclonal antibody

Swiss-Prot :O60674

Host :Rabbit

Reactivity :Human,Mouse,Rat,Chicken,Pig,Zebrafish

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-JAK2 (Tyr1007) polyclonal antibody detects endogenous levels of JAK2 protein only when phosphorylated at Tyr1007.

BiowMW :130KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

Immunogen :Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 1007.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of JAK2 (Phospho-Y1007) expression in HeLa (A), TF1 (B), NIH3T3 (C), rat kidney (D) whole cell lysates.

Immunohistochemical analysis of JAK2 (Phospho-Y1007) staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of JAK2 (Phospho-Y1007) staining in Jurkat cells.

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