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CHRNA7 polyclonal antibody

货号: BS79987

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS79987

Product Name :CHRNA7 polyclonal antibody

Swiss-Prot :P36544

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CHRNA7 polyclonal antibody detects endogenous levels of CHRNA7 protein.

BiowMW :53kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NACHRA7; Neuronal acetylcholine receptor subunit alpha-7

Immunogen :Recombinant fusion protein of human CHRNA7(NP_001177384.1).

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CHRNA7 expression in SGC7901 (A), mouse heart (B), rat brain (C) whole cell lysates.

Immunohistochemical analysis of CHRNA7 staining in rat brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of CHRNA7 staining in L929 cells.

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