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VHL polyclonal antibody

货号: BS79552

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS79552

Product Name :VHL polyclonal antibody

Swiss-Prot :P40337

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VHL polyclonal Antibody detects endogenous levels of VHL protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human VHL.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of VHL expression in C6 (A), H1792 (B), HEK293T (C) whole cell lysates.

Immunohistochemical analysis of VHL staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of VHL staining in AGS cells.

免疫沉淀（IP）