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APP polyclonal antibody

货号: BS78042

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :BS78042

Product Name :APP polyclonal antibody

Swiss-Prot :P05067

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:50 - 1:100|IF/ICC,1:50 - 1:200

Background :This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :APP polyclonal antibody detects endogenous levels of APP protein.

BiowMW :100-140KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :A4; AD1; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human APP.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of APP expression in HEK293T (A), mouse brain (B), mouse heart (C), H9C2 (D) whole cell lysates.

Immunohistochemical analysis of APP staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of APP staining in HeLa cells.