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[KO Validated] PHD2/EGLN1 polyclonal antibody

货号: BS75841

价格：￥ 1500

货期：现货（1-2个工作日）

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No. :BS75841

Product Name :[KO Validated] PHD2/EGLN1 polyclonal antibody

Swiss-Prot :Q9GZT9

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PHD2/EGLN1 polyclonal antibody detects endogenous levels of PHD2/EGLN1 protein

BiowMW :46KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :C1orf12; Egl nine homolog 1; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20

Immunogen :Recombinant full length protein of human PHD2/EGLN1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PHD2/EGLN1 expression in SHSY5Y (A), Hela (B), COS7 (C) whole cell lysates.

Immunohistochemical analysis of PHD2/EGLN1 staining in human kidney formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of PHD2/EGLN1 staining in MCF7 cells.