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AChR alpha 7 polyclonal antibody

货号: BS66283

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS66283

Product Name :AChR alpha 7 polyclonal antibody

Swiss-Prot :P36544

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200

Background :The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :AChR alpha 7 polyclonal antibody detects endogenous levels of AChR alpha 7 protein.

BiowMW :53kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NACHRA7; Neuronal acetylcholine receptor subunit alpha-7

Immunogen :Recombinant fusion protein of human AChR alpha 7.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of AChR alpha 7 expression in SGC7901 (A), mouse heart (B), rat brain (C) whole cell lysates.

Immunohistochemical analysis of AChR alpha 7 staining in rat brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of AChR alpha 7 staining in L929 cells.

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