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WNT1 polyclonal antibody

货号: BS66282

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS66282

Product Name :WNT1 polyclonal antibody

Swiss-Prot :P04628

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine, Monkey, Pig

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :WNT1 polyclonal antibody detects endogenous levels of WNT1 protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :INT1; Proto-oncogene Wnt-1; Proto-oncogene Int-1 homolog

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human WNT1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of WNT1 expression in HEK293T (A), SP2/0 (B), H9C2 (C), WI38 (D), NIH3T3 (E) whole cell lysates.

Immunohistochemical analysis of WNT1 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of WNT1 staining in H9C2 cells.

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