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GPR43 polyclonal antibody

货号: BS65586

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS65586

Product Name :GPR43 polyclonal antibody

Swiss-Prot :O15552

Host :Rabbit

Reactivity :Human

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:100 - 1:500

Background :G protein-coupled receptors provide attractive targets for drug therapy due to the sheer size and diversity of ligands within this receptor family. G protein-coupled receptor (GPR) GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled receptors that are tandemly encoded at a single chromosomal locus in both humans and mice. GPR43 functions as a ligand for short chain fatty acids (SCFAs), notably acetate and propionate. Bacteria in the gut produce high concentrations of SCFAs, which are subsequently released in the bloodstream, where they exert cellular effects on blood leukocytes, including calcium release, ERK1/2 activation, and inhibition of cAMP accumulation. These effects indicate a role for GPR43 in the recruitment of leukocytes, particularly polymorphonuclear cells, to sites of bacterial infection.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :GPR43 polyclonal Antibody detects endogenous levels of GPR43 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GPR43; Free fatty acid receptor 2; G-protein coupled receptor 43

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR43.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of GPR43 expression in THP1 (A) whole cell lysates.

Immunohistochemical analysis of GPR43 staining in human tonsil formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of GPR43 staining in THP1 cells.

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