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ATF6 polyclonal antibody

货号: BS6476

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6476

Product Name :ATF6 polyclonal antibody

Swiss-Prot :P18850

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC,IHC

Application_all :WB,1:500 - 1:2000|IF/ICC,1:50 - 1:200|IHC,1:50 - 1:200

Background :This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ATF6 polyclonal antibody detects endogenous levels of ATF6 protein.

BiowMW :90-100KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; ATF6-alpha

Immunogen :KLH-conjugated synthetic peptide of human ATF6.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of ATF6 expression in K562 (A), PC3 (B), mouse heart (C) whole cell lysates.

Immunohistochemical analysis of ATF6 staining in rat ovary formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of ATF6 staining in A549 cells.

Hydrogen sulfide protects against endoplasmic reticulum stress and mitochondrial injury in nucleus pulposus cells and ameliorates intervertebral disc degeneration

JournalPharmacological Research

ApplicationWB

IF5.893

SpeciesHuman

PMID28087442
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood–Brain Barrier Damage

JournalFrontiers in Pharmacology

ApplicationWB

IF3.845

SpeciesMouse

PMID28959203
Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation

JournalWorld Journal Of Gastroenterology

ApplicationWB

IF3.665

SpeciesHuman

PMID28246472
Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling

JournalCell Cycle

ApplicationWB

IF3.259

SpeciesHuman

PMID26066647
Endoplasmic Reticulum Stress Promotes Sorafenib Resistance via miR-188-5p/hnRNPA2B1 mediated upregulation of PKM2 in Hepatocellular Carcinoma

JournalMolecular Therapy-Nucleic Acids

ApplicationWB,IHC

IF8.886

SpeciesHuman

PMID34786210