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Phospho-CREB1-S133 polyclonal antibody

货号: BS6345

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS6345

Product Name :Phospho-CREB1-S133 polyclonal antibody

Swiss-Prot :P16220

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine, Chicken, Pig, Zebrafish

Applications :WB, IHC, IF/ICC, IP

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200|IF/ICC,1:50 - 1:200|IP,1:10 - 1:100

Background :This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Phospho-CREB1-S133 polyclonal antibody detects endogenous levels of CREB1 protein only when phosphorylated at Ser133.

BiowMW :43kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1

Immunogen :Synthetic phosphopeptide derived from human CREB1 around the phosphorylation site of Serine 133.

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-CREB1-S133 expression in C6 (A), NIH3T3 (B), HEK293T (C), H1792 (D) whole cell lysates.

Immunohistochemical analysis of Phospho-CREB1-S133 staining in human breast cancer formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of Phospho-CREB1-S133 staining in H460 cells.

The Involvement of NR2B and tau Protein in MG132-Induced CREB Dephosphorylation

JournalJournal Of Molecular Neuroscience

ApplicationWB

IF2.577

SpeciesHuman

PMID28424976
Semen Ziziphi Spinosae affects circadian rhythm of the cAMP signaling pathway by BMAL1-clockophagy to improve sleep disorders in depression

JournalPHYTOMEDICINE

ApplicationWB,IF

IF8.3

SpeciesMouse

PMID41175587