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IL18BP polyclonal antibody

货号: BS6312

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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No. :BS6312

Product Name :IL18BP polyclonal antibody

Swiss-Prot :O95998

Host :Rabbit

Reactivity :Human, Rat

Applications :WB, IHC, IF/ICC

Application_all :WB,1:500 - 1:2000|IHC,1:50 - 1:200|IF/ICC,1:50 - 1:100

Background :IL-18 (also referred to as IL-1γ) has been shown to augment the secretion of IFN-γ from T lymphocytes and to increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1α and IL-β, respectively, over the twelve β-strands of the β-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1β pro-domain, which must be cleaved by the serine protease ICE for optimal secretion and biological activity. IL-18, which was originally described as IGIF (IFN-γ-inducing factor), IL-18 is induced in mouse liver subsequent to challenge with lipopolysaccharide (LPS). IL-18 binding protein (IL-18BP) functions as an inhibitor of the early Th1 response by binding to IL-18 and inhibiting IFN-γ production. IL-18BP is a member of the immunoglobulin superfamily and shares some homology to IL-1RII.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL18BP polyclonal antibody detects endogenous levels of IL18BP protein.

BiowMW :~ 40 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Interleukin-18-binding protein; IL-18BP; Tadekinig-alfa

Immunogen :Recombinant full length Human IL18BP.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of IL18BP expression in Hela (A) whole cell lysates.

Immunohistochemical analysis of IL18BP staining in mouse heart formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of IL18BP staining in A549 cells.

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