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USP15 polyclonal antibody

货号: BS61734

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS61734

Product Name :USP15 polyclonal antibody

Swiss-Prot :Q9Y4E8

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP15 (ubiquitin specific peptidase 15), also known as UNPH4, is a member of the peptidase C19 family of proteins. Expressed in kidney, liver, placenta, ovary, lung, thymus, heart and skeletal muscle, USP15 localizes to the cytoplasm and the nucleus, contains one DUSP domain and functions as a deubiquitinating enzyme that cleaves ubiquitin residues from both ubiquitinylated proteins and ubiquitin-fused precursors, thereby saving these proteins from proteasomal degradation. Via its DUSP domain, USP15 plays a role in the regulation of the COP9 signalosome (CSN) complex. Three isoforms exist for USP15 due to alternative splicing events.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :USP15 polyclonal antibody detects endogenous levels of USP15 protein.

BiowMW :~ 112 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0529; Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human USP15.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of USP15 expression in A549 (A), SKOVCAR3 (B), HEK293T (C), H9C2 (D), AML12 (E) whole cell lysates.