产品类别

联系我们

电话:18013895086

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

MyD88 (V220) polyclonal antibody

货号: BS3521

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3521

Product Name :MyD88 (V220) polyclonal antibody

Swiss-Prot :Q99836

Host :Rabbit

Reactivity :Human, Mouse, Rat, Bovine, Monkey, Pig, Sheep

Applications :WB, IF/ICC,IHC

Application_all :WB,1:500 - 1:1000|IF/ICC,1:50 - 1:200|IHC,1:100 - 1:500

Background :The myeloid differentiation protein MyD88 was originally characterized as a protein upregulated in myeloleukemic cells following IL-6-induced growth arrest and terminal differentiation. MyD88 is now known to function as an adaptor protein for the association of IRAK with the IL-1 receptor. MyD88 is functionally homologous to the adaptor protein tube in the Toll signaling pathway of Drosophilia, and both proteins are members of the Toll/IL-1R superfamily. MyD88 contains a characteristic N-terminal death domain that is essential for NFκB activation and an adjacent Toll/IL-1R homology domain (TIR domain). Collectively, these domains enable the protein-protein interactions of MyD88 with IRAK and the IL-1 receptor complex.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MyD88 (V220) polyclonal antibody detects endogenous levels of MyD88 protein.

BiowMW :~ 33, 31, 28 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Toll-like Receptor signaling,

Alternative Name :Myeloid differentiation primary response protein MyD88

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MYD88.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of MYD88 expression in HEK293T (A), Hela (B), mouse lung (C), mouse muscle (D), mouse spleen (E), rat muscle (F), rat spleen (G) whole cell lysates.

Immunohistochemical analysis of MYD88 staining in human brain formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of MYD88 staining in Jurkat cells.

Toll-Like Receptors 2 and 4 Predict New-Onset Atrial Fibrillation in Acute Myocardial Infarction Patients

JournalInternational Heart Journal

ApplicationWB

IF1.906

SpeciesHuman

PMID29375116
Effects of borneol combined with astragaloside IV and Panax notoginseng saponins regulation of microglia polarization to promote neurogenesis after cerebral ischaemia

JournalJOURNAL OF PHARMACY AND PHARMACOLOGY

ApplicationWB

IF4.81

SpeciesRat

PMID37185938
Low-dose radiation ameliorates PM2.5-induced lung injury through non-canonical TLR1/TLR2-like receptor pathways modulated by Akkermansia muciniphila

JournalECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ApplicationIHC,WB

IF6.2

SpeciesMouse,Human

PMID39752914
Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway

JournalBMC Endocrine Disorders

ApplicationIHC

IF2.8

SpeciesMouse

PMID39920713
Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization

JournalINTERNATIONAL JOURNAL OF HYPERTHERMIA

ApplicationWB

IF3

SpeciesRat

PMID40376840