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CD4 (10H8) monoclonal antibody（KU）

货号: MB8502

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB8502

Product Name :CD4 (10H8) monoclonal antibody（KU）

Swiss-Prot :P01730

Host :Mouse

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell and recruits the tyrosine kinase Lck, which is essential for T cell activation.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD4 ( 10H8) monoclonal antibody detects endogenous levels of CD4 protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,

Alternative Name :T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3

Immunogen :Synthetic peptide, corresponding to amino acids Human CD4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD4 (10H8) mAb at 1:1000 dilution Lane1:Jurkat whole cell lysate(30ug) Lane2:THP-1 whole cell lysate(30ug)

Sequential administration of GM-CSF and IL-2 surface-modified MB49 cells vaccines against the metastatic bladder cancer

JournalUrologic Oncology-Seminars And Original Investigations

ApplicationIHC

IF3.498

SpeciesMouse

PMID