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Integrin alpha 11 monoclonal antibody

货号: MB67244

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67244

Product Name :Integrin alpha 11 monoclonal antibody

Swiss-Prot :Q9UKX5

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Integrin α11, also known as type I collagen receptor, is a single-pass type I transmembrane protein that mediates cell-matrix adhesion and is part of the family of integrins that play a pivotal role in regulation processes of cell proliferation, differentiation, migration, tumor invasion, and metastasis. Integrin α11 is highly expressed in embryonic fibroblasts and myofibroblasts and to varying degrees in the cytoplasm of most human tissues. In non-small cell lung cancers, integrin α11 overexpression correlates with tumorigenicity and formation of secondary metastatic lesions by increasing the migration and invasion capacity. TGFβ activation of integrin α11 results in significant upregulation and overexpression by cancer associated fibroblasts in the tumor stroma; therefore, it has been used as a prognostic marker in certain cancers. As a receptor for type I collagen, which is found in fibrotic tissue of the liver, lung, and kidney, integrin α11 colocalizes with α-smooth muscle actin. Type I collagen is the most abundant form in the body, indicating a role for targeting integrin α11 in the therapeutic intervention of fibrotic disease.

Product :Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Integrin alpha 11 protein.

BiowMW :~ 160 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, MAPK Erk in Growth and Differentiation Pathway(, PI3K AKT signaling

Alternative Name :Integrin alpha-11

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Integrin alpha 11. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Integrin alpha 11 expression in Hela (A), A549 (B), human uterus (C) whole cell lysates.