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Smurf2 monoclonal antibody

货号: MB67214

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67214

Product Name :Smurf2 monoclonal antibody

Swiss-Prot :Q9HAU4

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :Smad ubiquitin regulatory factor 2 (Smurf2) is a HECT domain E3 ubiquitin ligase. It was initially identified as an inhibitor of TGF-β/BMP signaling by targeting R-Smads and TGF type I receptor for ubiquitination and degradation. Subsequent studies have revealed its role in neuronal and planar cell polarity, as well as in the senescence response and suppression of tumorigenesis. Smurf2 has a broad range of substrates including RUNX2, AMSH, Rap1B, and RNF11. Smurf2 is widely expressed in various tissues. The C2 domain of Smurf2 inhibits its catalytic activity by interacting with the HECT domain. Research studies have shown that Smurf2 functions as a tumor suppressor by maintaining genomic stability through targeting RNF20.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Smurf2 protein.

BiowMW :~ 80 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :TGFβ Smad signaling

Alternative Name :E3 ubiquitin-protein ligase SMURF2; hSMURF2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2

Immunogen :Recombinant fusion protein of human Smurf2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Smurf2 expression in MDAMB231 (A), U2OS (B) whole cell lysates.