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ECT2 monoclonal antibody

货号: MB67210

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB67210

Product Name :ECT2 monoclonal antibody

Swiss-Prot :Q9H8V3

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Epithelial cell transforming sequence 2 (ECT2), a guanine nucleotide exchange factor (GEF), catalyzes the exchange of GDP for GTP. The nuclear GEF activity of ECT2 is essential for Kras-Trp53 lung tumorigenesis. This transformation requires ECT2-mediated rRNA synthesis. In addition, PKCι-dependent phosphorylation of ECT2 is necessary for the oncogenic activity of this protein. Furthermore, ECT2 has been implicated as a cancer driver gene in certain subtypes of liver cancers. Research studies also show that, during matrix-directed cell migration, low membrane tension stimulates the formation of caveolae at the rear end of moving cells. ECT2 is recruited to the caveolae and activates RhoA, causing F-actin organization and rear retraction.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of ECT2 protein.

BiowMW :~ 104 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein ECT2; Epithelial cell-transforming sequence 2 oncogene

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human ECT2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of ECT2 expression in 293T (A) whole cell lysates.

免疫沉淀（IP）