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CARD9 monoclonal antibody

货号: MB67203

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB67203

Product Name :CARD9 monoclonal antibody

Swiss-Prot :Q9H257

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :CARD9 is a caspase recruitment domain (CARD)-containing adaptor protein expressed by myeloid cells. It is required for antifungal immunity downstream of pathogen detection by C-type lectin receptors (CLRs) such as Dectin-1. Recognition of carbohydrates on fungal cell walls by CLRs leads to activation of the tyrosine kinase Syk, followed by activation of PKCδ. PKCδ phosphorylates CARD9, enabling the assembly of a complex containing CARD9 and Bcl10. This complex activates NF-κB, resulting in upregulation of inflammatory cytokines important for initiation of adaptive immunity. CARD9 was also shown to be important for the induction of IL-1β, downstream of the viral nucleic acid sensor RIG-I, as well as for the generation of reactive oxygen species important for bacterial killing by macrophages.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CARD9 protein.

BiowMW :~ 64 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Caspase recruitment domain-containing protein 9; hCARD9

Immunogen :Recombinant fusion protein of human CARD9. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CARD9 expression in K562 (A), HL60 (B) whole cell lysates.

免疫沉淀（IP）