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WBP2 monoclonal antibody

货号: MB67170

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67170

Product Name :WBP2 monoclonal antibody

Swiss-Prot :Q969T9

Host :Mouse

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :WW-domain binding protein 2 (WBP2) is an adaptor protein first identified in a screen for proteins that interact with YAP1. WBP2 was subsequently shown to bind other WW domain-containing proteins, including TAZ and NEDD4-like ubiquitin-protein ligases. There is strong evidence for a conserved functional role for WBP2 in the Hippo kinase tumor suppressor pathway. WBP2 interaction is required for the oncogenic properties of TAZ in breast cancer cells and the growth-promoting properties of the YAP homolog Yorkie in Drosophila. In vitro studies have also suggested that WBP2 may act as a transcriptional co-activator of both estrogen and progesterone receptors; this interaction was shown to be dependent upon tyrosine phosphorylation of WBP2 by c-Src and c-Yes kinases.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of WBP2 protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :WW domain-binding protein 2; WBP-2

Immunogen :Recombinant fusion protein of human WBP2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of WBP2 expression in mouse heart (A), A549 (B), HL60 (C), 293 (D), A2058 (E) whole cell lysates.

免疫沉淀（IP）