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BAD (Phospho-S155) monoclonal antibody

货号: MB67133

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67133

Product Name :BAD (Phospho-S155) monoclonal antibody

Swiss-Prot :Q92934

Host :Mouse

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Bad is a proapoptotic member of the Bcl-2 family that promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL. Survival factors, such as IL-3, inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser136. Phosphorylation at these sites promotes binding of Bad to 14-3-3 proteins to prevent an association between Bad with Bcl-2 and Bcl-xL. Akt phosphorylates Bad at Ser136 to promote cell survival. Bad is phosphorylated at Ser112 both in vivo and in vitro by p90RSK and mitochondria-anchored PKA. Phosphorylation at Ser155 in the BH3 domain by PKA plays a critical role in blocking the dimerization of Bad and Bcl-xL.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of BAD (pS155) protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis，ErbB HER Signaling，MAPK Erk in Growth and Differentiation Pathway(，Inhibition of Apoptosis，Mitochondrial Control of Apoptosis，PI3K AKT signaling

Alternative Name :BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter

Immunogen :KLH-conjugated synthetic peptide of human BAD (pS155). The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot analysis of BAD (pS155) expression in 293 transfected with FlagBad (A) whole cell lysates.